Pgam1^tm1.1Hiko
Targeted Allele Detail

Summary

• Symbol: Pgam1^tm1.1Hiko
• Name: phosphoglycerate mutase 1; targeted mutation 1.1, Hiroshi Kondoh
• MGI ID: MGI:6473536
• Synonyms: Pgam1^flox
• Gene: Pgam1 Location: Chr19:41900362-41907099 bp, + strand Genetic Position: Chr19, 35.44 cM
• Alliance: Pgam1^tm1.1Hiko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293746
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted into intron 1 and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 2 and 3 floxed. (J:293746)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pgam1 Mutation: 22 strains or lines available

References

• Original: J:293746 Toriyama K, et al., T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses. Commun Biol. 2020 Jul 24;3(1):394
• All: 1 reference(s)