Gpr141^tm1Rygo
Targeted Allele Detail

Summary

• Symbol: Gpr141^tm1Rygo
• Name: G protein-coupled receptor 141; targeted mutation 1, Ryo Goitsuka
• MGI ID: MGI:6473311
• Gene: Gpr141 Location: Chr13:19933852-20008427 bp, - strand Genetic Position: Chr13, 7.04 cM
• Alliance: Gpr141^tm1Rygo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:350371
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The genomic fragment encompassing the fifth exon of the gene, containing the whole protein coding region and 3' untranslated regions, was replaced by a DNA cassette containing a loxP-flanked neomycin-resistance gene under the control of a phosphoglycerate kinase 1 (Pgk1) promoter. (J:350371)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpr141 Mutation: 15 strains or lines available

References

• Original: J:350371 Sawabe A, et al., The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor. J Leukoc Biol. 2024 Apr 29;115(5):935-945
• All: 1 reference(s)