Cbl^tm1(CBL)Homy
Targeted Allele Detail

Summary

• Symbol: Cbl^tm1(CBL)Homy
• Name: Cbl proto-oncogene; targeted mutation 1, Hiroaki Honda
• MGI ID: MGI:6473289
• Synonyms: Cbl^{tm1(CBL*Q367P)Homy}, Cbl^WT
• Gene: Cbl Location: Chr9:44054273-44145346 bp, - strand Genetic Position: Chr9, 24.72 cM
• Alliance: Cbl^tm1(CBL)Homy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241533
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5 to 9 were replaced with a loxP flanked human CBL, and a human CBL having Q367P variant was inserted the downstream. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:241533)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbl Mutation: 57 strains or lines available

References

• Original: J:241533 Nakata Y, et al., Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia. Blood. 2017 Apr 13;129(15):2148-2160
• All: 1 reference(s)