Cbltm1(CBL)Homy
Targeted Allele Detail
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Symbol: |
Cbltm1(CBL)Homy |
Name: |
Casitas B-lineage lymphoma; targeted mutation 1, Hiroaki Honda |
MGI ID: |
MGI:6473289 |
Synonyms: |
Cbltm1(CBL*Q367P)Homy, CblWT |
Gene: |
Cbl Location: Chr9:44054273-44145346 bp, - strand Genetic Position: Chr9, 24.72 cM
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Alliance: |
Cbltm1(CBL)Homy page
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Germline Transmission: |
Earliest citation of germline transmission:
J:241533
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Conditional ready, Humanized sequence, Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 5 to 9 were replaced with a loxP flanked human CBL, and a human CBL having Q367P variant was inserted the downstream. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette.
(J:241533)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cbl Mutation: |
57 strains or lines available
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Original: |
J:241533 Nakata Y, et al., Acquired expression of CblQ367P in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia. Blood. 2017 Apr 13;129(15):2148-2160 |
All: |
1 reference(s) |
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