Dmrt1^tm1.2Zark
Targeted Allele Detail

Summary

• Symbol: Dmrt1^tm1.2Zark
• Name: doublesex and mab-3 related transcription factor 1; targeted mutation 1.2, David Zarkower
• MGI ID: MGI:6471070
• Synonyms: Dmrt1^flox
• Gene: Dmrt1 Location: Chr19:25483070-25581692 bp, + strand Genetic Position: Chr19, 20.45 cM, cytoband C2-C3
• Alliance: Dmrt1^tm1.2Zark page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65541
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct was designed to insert a loxP site upstream of exon 1 and an FRT-flanked neomycin cassette followed by a loxP site downstream of exon 1. The loxP-flanked region includes the DM domain, a zinc finger-like DNA-binding motif, as well as the transcription start site and part of the first intron. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:65541)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dmrt1 Mutation: 47 strains or lines available

References

• Original: J:65541 Raymond CS, et al., Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. Genes Dev. 2000 Oct 15;14(20):2587-95
• All: 1 reference(s)