Slc16a1^tm1.1Lupel
Targeted Allele Detail

Summary

• Symbol: Slc16a1^tm1.1Lupel
• Name: solute carrier family 16 (monocarboxylic acid transporters), member 1; targeted mutation 1.1, Luc Pellerin
• MGI ID: MGI:6470987
• Synonyms: MCT1^fE5, MCT1^fl
• Gene: Slc16a1 Location: Chr3:104545984-104565778 bp, + strand Genetic Position: Chr3, 45.7 cM
• Alliance: Slc16a1^tm1.1Lupel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296552
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT site flanked neomycin resistance gene cassette were inserted into intron 4 and a second loxP site into intron 5. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 5 floxed. (J:296552)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc16a1 Mutation: 22 strains or lines available

References

• Original: J:296552 Zhang J, et al., Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization. Cell Metab. 2020 Jun 2;31(6):1136-1153.e7
• All: 5 reference(s)