Sphk2^tm1.1Pxia
Targeted Allele Detail

Summary

• Symbol: Sphk2^tm1.1Pxia
• Name: sphingosine kinase 2; targeted mutation 1.1, Pu Xia
• MGI ID: MGI:6470113
• Synonyms: Sphk2^fl
• Gene: Sphk2 Location: Chr7:45358891-45367426 bp, - strand Genetic Position: Chr7, 29.45 cM
• Alliance: Sphk2^tm1.1Pxia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296267
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites. An FRT-flanked neomycin selection cassette was also inserted and removed via Flp-mediated recombination leaving exon 2 floxed. (J:296267)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sphk2 Mutation: 38 strains or lines available

References

• Original: J:296267 Aji G, et al., Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24434-24442
• All: 1 reference(s)