Rtp4^em#Xzs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rtp4^em#Xzs
• Name: receptor transporter protein 4; endonuclease-mediated mutation, Xin-zhuan Su
• MGI ID: MGI:6470099
• Synonyms: Rtp4^-
• Gene: Rtp4 Location: Chr16:23339041-23432972 bp, + strand Genetic Position: Chr16, 14.55 cM, cytoband B1
• Alliance: Rtp4^em#Xzs page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The first and second coding exons (1 and 2) were targeted with two sgRNAs (5-ccccgatgacttcagtacttggg-3 and 5- cctcagacccggaatacggatttt-3) using CRISPR/Cas9 technology. Five founder mice were created with at least two different size deletions, both including the end of exon 1, intron 1 and the start of exon 2. The pound # sign is used in the allele symbol because which mouse line was used, or if a mixture was used, is not specified. (J:293929)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rtp4 Mutation: 18 strains or lines available

References

• Original: J:293929 He X, et al., RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology. Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19465-19474
• All: 1 reference(s)