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Ace2tm1(ACE2)Dwnt
Targeted Allele Detail
Nomenclature
Symbol: Ace2tm1(ACE2)Dwnt
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; targeted mutation 1, David Wentworth
MGI ID: MGI:6469881
Synonyms: hACE2 KI
Gene: Ace2  Location: ChrX:162922338-162971414 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:296356
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Ace2tm1(ACE2)Dwnt expresses 1 gene
 
Mutation detailsThe targeting construct is designed to replace exon 2 with a human ACE2 cDNA inserted in-frame with the endogenous initiation codon. in addition, a loxP site is placed upstream of the ACE2 cDNA and a FRT-flanked neomycin resistance (neo) cassette and a second loxP site is placed downstream of the ACE2 cDNA. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:296356)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:  23 strains or lines available
References
Original:  J:296356 Zhou B, et al., SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility. bioRxiv. 2020;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/07/2021
MGI 6.17
The Jackson Laboratory