Oprm1^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm1.1Ics
• Name: opioid receptor, mu 1; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:6469457
• Synonyms: MOR-Venus, Oprm1^Venus
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296331
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert Venus yellow fluorescent protein cDNA into exon 4 and replace the endogenous STOP codon with a 5aa linker. A self-excising loxP-flanked cassette, containing a neomycin resistance (neo) cassette and a FRT-flanked protamine-cre, was placed downstream. (J:296331)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 53 strains or lines available

References

• Original: J:296331 Ehrlich AT, et al., Biased Signaling of the Mu Opioid Receptor Revealed in Native Neurons. iScience. 2019 Apr 26;14:47-57
• All: 1 reference(s)