Hspg2^tm3.1Soin
Targeted Allele Detail

Summary

• Symbol: Hspg2^tm3.1Soin
• Name: perlecan (heparan sulfate proteoglycan 2); targeted mutation 3.1, Raija Soininen
• MGI ID: MGI:6468552
• Gene: Hspg2 Location: Chr4:137196080-137297941 bp, + strand Genetic Position: Chr4, 69.93 cM
• Alliance: Hspg2^tm3.1Soin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82809
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 91 of the perlecan gene was first replaced by a loxP flanked neo cassette by homologous recombination. The cassette was then removed by breeding with a mouse carrying the Cre recombinase. Since the reading frame is not altered by the deletion, a protein lacking 19 amino acids is produced. The deletion leads to loss of the C-terminal glycosaminoglycan attachment site. (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hspg2 Mutation: 311 strains or lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 1 reference(s)