Orai2^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Orai2^tm1.1Arte
• Name: ORAI calcium release-activated calcium modulator 2; targeted mutation 1.1. TaconicArtemis
• MGI ID: MGI:6468540
• Synonyms: Orai2^fl
• Gene: Orai2 Location: Chr5:136176313-136199567 bp, - strand Genetic Position: Chr5, 75.84 cM
• Alliance: Orai2^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296268
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT-flanked neomycin resistance gene were inserted upstream of exon 3 and a F3 site-flanked puromycin resistance gene and second loxP site were inserted downstream of exon 3. Flp-mediated recombination removed the neomycin and puromycin selection markers leaving exon 3 floxed. (J:296268)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Orai2 Mutation: 13 strains or lines available

References

• Original: J:296268 Grimes D, et al., ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24403-24414
• All: 1 reference(s)