Cd44^tm1.2Mka
Targeted Allele Detail

Summary

• Symbol: Cd44^tm1.2Mka
• Name: CD44 antigen; targeted mutation 1.2, Michael Karin
• MGI ID: MGI:6468311
• Synonyms: cd44^-
• Gene: Cd44 Location: Chr2:102641486-102732010 bp, - strand Genetic Position: Chr2, 54.13 cM
• Alliance: Cd44^tm1.2Mka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296234
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was flanked with loxP sites. An frt-flanked neomycin selection cassette was removed in ES cells prior to the creation of chimeric mice. Cre-mediated recombination in the germline resulted in the deletion of exon 3. (J:296234)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd44 Mutation: 74 strains or lines available

References

• Original: J:296234 Ma J, et al., Cluster of differentiation 44 promotes osteosarcoma progression in mice lacking the tumor suppressor Merlin. Int J Cancer. 2020 Jun 11
• All: 3 reference(s)