Il6^tm2.1Jho
Targeted Allele Detail

Summary

• Symbol: Il6^tm2.1Jho
• Name: interleukin 6; targeted mutation 2.1, Juan Hidalgo
• MGI ID: MGI:6468229
• Synonyms: Il6^DIOex2
• Gene: Il6 Location: Chr5:30218112-30224973 bp, + strand Genetic Position: Chr5, 15.7 cM
• Alliance: Il6^tm2.1Jho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:296263
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An inverted exon 2 flanked with lox2272 and loxP sites replaced exon 2. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of exon 2. (J:296263)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il6 Mutation: 37 strains or lines available

References

• Original: J:296263 Sanchis P, et al., A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis. J Neuroinflammation. 2020 Oct 15;17(1):304
• All: 2 reference(s)