Pdgfra^tm1.1Msas
Targeted Allele Detail

Summary

• Symbol: Pdgfra^tm1.1Msas
• Name: platelet derived growth factor receptor, alpha polypeptide; targeted mutation 1.1, Masakiyo Sasahara
• MGI ID: MGI:6467929
• Synonyms: Pdgfra^flox
• Gene: Pdgfra Location: Chr5:75312953-75358876 bp, + strand Genetic Position: Chr5, 39.55 cM
• Alliance: Pdgfra^tm1.1Msas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250501
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted to flank exons 4 and 5. The frt-flanked neomycin selection cassette was removed in the germline via FLP-mediated recombination. (J:250501)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfra Mutation: 88 strains or lines available

References

• Original: J:250501 Horikawa S, et al., PDGFRalpha plays a crucial role in connective tissue remodeling. Sci Rep. 2015 Dec 7;5:17948
• All: 4 reference(s)