Irf2^tm1.1Toht
Targeted Allele Detail

Summary

• Symbol: Irf2^tm1.1Toht
• Name: interferon regulatory factor 2; targeted mutation 1.1, Toshiaki Ohteki
• MGI ID: MGI:6467796
• Gene: Irf2 Location: Chr8:47192767-47300493 bp, + strand Genetic Position: Chr8, 26.42 cM, cytoband B2
• Alliance: Irf2^tm1.1Toht page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291426
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 to 5 were flanked by loxP sites and an FRT-flanked PGK-gb2-neo cassette was inserted downstream of the second loxP site. Flp-mediated recombination removed the selection cassette leaving exons 3-5 floxed. (J:291426)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf2 Mutation: 24 strains or lines available

References

• Original: J:291426 Sato T, et al., Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages. Nat Cell Biol. 2020 Jul 20
• All: 2 reference(s)