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Ttntm4.1(birA)Mgot
Targeted Allele Detail
Summary
Symbol: Ttntm4.1(birA)Mgot
Name: titin; targeted mutation 4.1, Michaal Gotthardt
MGI ID: MGI:6467406
Synonyms: TiZ-BioIDp
Gene: Ttn  Location: Chr2:76534324-76812891 bp, - strand  Genetic Position: Chr2, 45.13 cM, cytoband D
Alliance: Ttntm4.1(birA)Mgot page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:292446
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutation:    Insertion
 
Mutation detailsThe E.coli bacterial birA (biotin ligase) gene was inserted in exon 28 at the transition of the Z-disc to the I-band and an FRT site, neomycin selection cassette, loxP site and FRT site were inserted downstream of exon 28. Flp-mediated recombination removed the neo cassette. (J:292446)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ttn Mutation:  1455 strains or lines available
References
Original:  J:292446 Rudolph F, et al., Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice. Nat Commun. 2020 Jun 19;11(1):3133
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory