Ttn^{tm4.1(birA)Mgot}
Targeted Allele Detail

Summary

• Symbol: Ttn^{tm4.1(birA)Mgot}
• Name: titin; targeted mutation 4.1, Michaal Gotthardt
• MGI ID: MGI:6467406
• Synonyms: TiZ-BioID^p
• Gene: Ttn Location: Chr2:76534324-76812891 bp, - strand Genetic Position: Chr2, 45.13 cM, cytoband D
• Alliance: Ttn^{tm4.1(birA)Mgot} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292446
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Insertion
• Mutation details: The E.coli bacterial birA (biotin ligase) gene was inserted in exon 28 at the transition of the Z-disc to the I-band and an FRT site, neomycin selection cassette, loxP site and FRT site were inserted downstream of exon 28. Flp-mediated recombination removed the neo cassette. (J:292446)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttn Mutation: 1456 strains or lines available

References

• Original: J:292446 Rudolph F, et al., Deconstructing sarcomeric structure-function relations in titin-BioID knock-in mice. Nat Commun. 2020 Jun 19;11(1):3133
• All: 1 reference(s)