Itpr1^tm1.1Chen
Targeted Allele Detail

Summary

• Symbol: Itpr1^tm1.1Chen
• Name: inositol 1,4,5-trisphosphate receptor 1; targeted mutation 1.1, Ju Chen
• MGI ID: MGI:6467335
• Gene: Itpr1 Location: Chr6:108190057-108528070 bp, + strand Genetic Position: Chr6, 49.74 cM
• Alliance: Itpr1^tm1.1Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:287527
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5. (J:287527)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itpr1 Mutation: 185 strains or lines available

References

• Original: J:287527 Yang F, et al., Inositol 1,4,5-trisphosphate receptors are essential for fetal-maternal connection and embryo viability. PLoS Genet. 2020 Apr;16(4):e1008739
• All: 1 reference(s)