P2ry2^tm1.2Bph
Targeted Allele Detail

Summary

• Symbol: P2ry2^tm1.2Bph
• Name: purinergic receptor P2Y, G-protein coupled 2; targeted mutation 1.2, Paul Herring
• MGI ID: MGI:6467261
• Synonyms: P2Y2R-KO
• Gene: P2ry2 Location: Chr7:100645775-100661260 bp, - strand Genetic Position: Chr7, 54.47 cM, cytoband F1
• Alliance: P2ry2^tm1.2Bph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262646
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The coding region of the gene was flanked with loxP sites and an frt-flanked neomycin selection cassette. The frt-flanked neomycin selection cassette and the loxP-flanked region were deleted via FLP and Cre-mediated recombination. (J:262646)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2ry2 Mutation: 16 strains or lines available

References

• Original: J:262646 Chen X, et al., Endothelial Cell-Specific Deletion of P2Y2 Receptor Promotes Plaque Stability in Atherosclerosis-Susceptible ApoE-Null Mice. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):75-83
• All: 1 reference(s)