Ddx3x^em1.1Tdk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ddx3x^em1.1Tdk
• Name: DEAD box helicase 3, X-linked; endonuclease-mediated mutation 1.1, Thirumala-Devi Kanneganti
• MGI ID: MGI:6466746
• Synonyms: Ddx3x KO
• Gene: Ddx3x Location: ChrX:13147261-13160222 bp, + strand Genetic Position: ChrX, 8.17 cM
• Alliance: Ddx3x^em1.1Tdk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to insert loxP sites in introns 6 and 14. Cre-mediated recombination in the germline resulted in the deletion of exons 7-14. (J:279977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddx3x Mutation: 9 strains or lines available

References

• Original: J:279977 Samir P, et al., DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019 Sep;573(7775):590-594
• All: 1 reference(s)