Nlrc3^tm1.1Tdk
Targeted Allele Detail

Summary

• Symbol: Nlrc3^tm1.1Tdk
• Name: NLR family, CARD domain containing 3; targeted mutation 1.1, Thirumala-Devi Kanneganti
• MGI ID: MGI:6466743
• Gene: Nlrc3 Location: Chr16:3762871-3794496 bp, - strand Genetic Position: Chr16, 2.32 cM
• Alliance: Nlrc3^tm1.1Tdk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240431
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette was inserted to flank exons 2 and 3. Cre-mediated recombination in the germline resulted in the deletion of a 2.5 kb genomic region, which is expected to result in deletion of 661 amino acids encoding the N-terminal caspase recruitment domain (also known as CARD) and the central nucleotide-binding domain (also known as NACHT) of the encoded protein. (J:240431)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrc3 Mutation: 53 strains or lines available

References

• Original: J:240431 Karki R, et al., NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016 Dec 12
• All: 2 reference(s)