Zbp1^em1Tdk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zbp1^em1Tdk
• Name: Z-DNA binding protein 1; endonuclease-mediated mutation 1, Thirumala-Devi Kanneganti
• MGI ID: MGI:6466718
• Synonyms: Zbp1^deltaZalpha2
• Gene: Zbp1 Location: Chr2:173048405-173060715 bp, - strand Genetic Position: Chr2, 95.83 cM, cytoband H3
• Alliance: Zbp1^em1Tdk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a deletion of the genomic sequences encoding the Zaplha2 domain of the protein. At the amino acid sequence level,this resulted in a Zalpha2 domain deletion in the encoded protein by joining residues at positions 76 and 151 and deleting residues at positions 77150. (J:295921)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbp1 Mutation: 29 strains or lines available

References

• Original: J:295921 Kesavardhana S, et al., The Zalpha2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development. J Biol Chem. 2020 Jun 12;295(24):8325-8330
• All: 4 reference(s)