Siglecf^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Siglecf^tm1.1Arte
• Name: sialic acid binding Ig-like lectin F; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:6466707
• Synonyms: Siglec-F^R114D
• Gene: Siglecf Location: Chr7:43000765-43008955 bp, + strand Genetic Position: Chr7, 28.25 cM, cytoband B3
• Alliance: Siglecf^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288980
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Exon 3 was replaced with one with a nucleotide substitution resulting in the amino acid substitutions of arginine with aspartic acid at position 114 (R114D). Flp-mediated recombination removed the selection cassette inserted into intron 5 and a puromycin cassette inserted into intron 9. Exons 6 through 9 remained floxed. (J:288980)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Siglecf Mutation: 52 strains or lines available

References

• Original: J:288980 McMillan SJ, et al., Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model. Immunol Lett. 2014 Jul;160(1):11-16
• All: 1 reference(s)