Nlrp1a^tm1Smas
Targeted Allele Detail

Summary

• Symbol: Nlrp1a^tm1Smas
• Name: NLR family, pyrin domain containing 1A; targeted mutation 1, Seth Masters
• MGI ID: MGI:6466653
• Gene: Nlrp1a Location: Chr11:70983062-71035530 bp, - strand Genetic Position: Chr11, 43.21 cM
• Alliance: Nlrp1a^tm1Smas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267658
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 3 was replaced with a neomycin selection cassette. (J:267658)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp1a Mutation: 64 strains or lines available

References

• Original: J:267658 Tye H, et al., NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease. Nat Commun. 2018 Sep 13;9(1):3728
• All: 1 reference(s)