Bscl2^em1Gliu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Bscl2^em1Gliu
• Name: BSCL2 lipid droplet biogenesis associated, seipin; endonuclease-mediated mutation 1, George Liu
• MGI ID: MGI:6466589
• Synonyms: Seipin^-
• Gene: Bscl2 Location: Chr19:8814831-8826047 bp, + strand Genetic Position: Chr19, 5.76 cM
• Alliance: Bscl2^em1Gliu page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a 701 bp deletion in the gene, including exon 2. (J:288248)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bscl2 Mutation: 35 strains or lines available

References

• Original: J:288248 Gao M, et al., GPAT3 deficiency alleviates insulin resistance and hepatic steatosis in a mouse model of severe congenital generalized lipodystrophy. Hum Mol Genet. 2020 Feb 1;29(3):432-443
• All: 1 reference(s)