Tnfrsf25^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Tnfrsf25^tm1.2Geno
• Name: tumor necrosis factor receptor superfamily, member 25; targeted mutation 1.2, Genoway
• MGI ID: MGI:6466583
• Synonyms: Dr3^-
• Gene: Tnfrsf25 Location: Chr4:152200391-152204576 bp, + strand Genetic Position: Chr4, 82.89 cM, cytoband E1
• Alliance: Tnfrsf25^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279191
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Two loxP sites were inserted flanking exons 2 to 5, and a positive selection neomycin gene flanked by FRT sites was inserted in the intron between exon 1 and 2. The FRT-flanked neomycin selection cassette was deleted via FLP-mediated recombination and exons 2-5 were deleted via Cre-mediated recombination. (J:279191)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf25 Mutation: 23 strains or lines available

References

• Original: J:279191 Shih DQ, et al., Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis. Mucosal Immunol. 2014 Nov;7(6):1492-503
• All: 3 reference(s)