Il21^{tm1.1(Katushka)Jedc}
Targeted Allele Detail

Summary

• Symbol: Il21^{tm1.1(Katushka)Jedc}
• Name: interleukin 21; targeted mutation 1.1 Joseph Edgar Craft
• MGI ID: MGI:6466569
• Synonyms: Il21-IRES-FP635 (Katushka), Il21^Kat
• Gene: Il21 Location: Chr3:37276908-37286785 bp, - strand Genetic Position: Chr3, 18.36 cM, cytoband B
• Alliance: Il21^{tm1.1(Katushka)Jedc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213697
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An IRES-FP-635 (Katsuhka) construct and a loxP-flanked neomycin selection cassette was inserted just after the stop codon of the gene. The neomycin selection cassette was removed via Cre-mediated recombination in the germline. (J:213697)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il21 Mutation: 43 strains or lines available

References

• Original: J:213697 Shulman Z, et al., Dynamic signaling by T follicular helper cells during germinal center B cell selection. Science. 2014 Aug 29;345(6200):1058-62
• All: 7 reference(s)