Il1r1^tm1.2Wme
Targeted Allele Detail

Summary

• Symbol: Il1r1^tm1.2Wme
• Name: interleukin 1 receptor, type I; targeted mutation 1.2, Werner Mueller
• MGI ID: MGI:6466557
• Synonyms: Il1r1 KO
• Gene: Il1r1 Location: Chr1:40264240-40356417 bp, + strand Genetic Position: Chr1, 18.81 cM
• Alliance: Il1r1^tm1.2Wme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:280512
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 5. An F3 flanked puromycin resistance cassette with a 3' loxP site was inserted downstream of exon 5. FLP and Cre-mediated recombination removed both selection cassettes and exon 5. (J:241494)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il1r1 Mutation: 37 strains or lines available

References

• Original: J:280512 Bageghni SA, et al., Cardiac fibroblast-specific p38alpha MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism. FASEB J. 2018 Sep;32(9):4941-4954
• All: 2 reference(s)