Ap2m1^tm1.2Vha
Targeted Allele Detail

Summary

• Symbol: Ap2m1^tm1.2Vha
• Name: adaptor-related protein complex 2, mu 1 subunit; targeted mutation 1.2, Volker Haucke
• MGI ID: MGI:6466554
• Synonyms: Ap2m1KO
• Gene: Ap2m1 Location: Chr16:20354230-20363659 bp, + strand Genetic Position: Chr16, 12.46 cM, cytoband 16
• Alliance: Ap2m1^tm1.2Vha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283074
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP and FRT flanked neo cassette was inserted downstream of exon 3 via homologous recombination. FLP-meditated recombination removed the neo cassette leaving exons 3 and 4 floxed, and Cre-mediated recombination in the germline resulted in the deletion of exon 2. (J:283074)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ap2m1 Mutation: 40 strains or lines available

References

• Original: J:283074 Fred SM, et al., Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2. J Biol Chem. 2019 Nov 29;294(48):18150-18161
• All: 1 reference(s)