Cyp26b1^tm2.1Hmd
Targeted Allele Detail

Summary

• Symbol: Cyp26b1^tm2.1Hmd
• Name: cytochrome P450, family 26, subfamily b, polypeptide 1; targeted mutation 2.1, Hiroshi Hamada
• MGI ID: MGI:6466546
• Synonyms: Cyp26b1 KO
• Gene: Cyp26b1 Location: Chr6:84548396-84570890 bp, - strand Genetic Position: Chr6, 36.45 cM
• Alliance: Cyp26b1^tm2.1Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294163
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted in intron 4 and an FRT flanked PGK-neomycin selection cassette folled by a second loxP site was inserted in the 3' untranslated region of exon 6. The selection cassette was subsequently removed by flp expression. Exons 5 and 6 were deleted in the germline via Cre-mediated recombination. (J:192725)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp26b1 Mutation: 33 strains or lines available

References

• Original: J:294163 Ono K, et al., Retinoic acid synthesis and autoregulation mediate zonal patterning of vestibular organs and inner ear morphogenesis. Development. 2020 Aug 7;147(15):dev192070
• All: 3 reference(s)