Tek^tm1.2Scba
Targeted Allele Detail

Summary

• Symbol: Tek^tm1.2Scba
• Name: TEK receptor tyrosine kinase; targeted mutation 1.2, Scott Baldwin
• MGI ID: MGI:6466536
• Synonyms: Tie2^-
• Gene: Tek Location: Chr4:94627526-94763213 bp, + strand Genetic Position: Chr4, 43.34 cM
• Alliance: Tek^tm1.2Scba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276877
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites were inserted to flank the minimal promoter and exon 1, which contains the start ATG codon and encode the first 17 amino acids. An frt-flanked neomycin selection cassette was removed via FLP-mediated recombination. Cre-mediated recombination resulted in the deletion of the minimal promoter and exon 1. (J:276877)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tek Mutation: 90 strains or lines available

References

• Original: J:276877 Qu X, et al., Tie2 regulates endocardial sprouting and myocardial trabeculation. JCI Insight. 2019 May 21;5
• All: 1 reference(s)