Itga6^tm3.1Egl
Targeted Allele Detail

Summary

• Symbol: Itga6^tm3.1Egl
• Name: integrin alpha 6; targeted mutation 3.1, Elisabeth Georges-Labouesse
• MGI ID: MGI:6460648
• Synonyms: alpha6^fl
• Gene: Itga6 Location: Chr2:71617236-71688761 bp, + strand Genetic Position: Chr2, 42.79 cM
• Alliance: Itga6^tm3.1Egl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites and a neomycin selection cassette were inserted to flank the exons encoding the transmembrane domain (TM) and the alternative cytoplasmic domains alpha6A and alpha6B. The neomycin selection cassette was removed via Cre-mediated recombination. (J:291945)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itga6 Mutation: 211 strains or lines available

References

• Original: J:291945 De Arcangelis A, et al., Hemidesmosome integrity protects the colon against colitis and colorectal cancer. Gut. 2017 Oct;66(10):1748-1760
• All: 5 reference(s)