Klra1^em1Wyok
Endonuclease-mediated Allele Detail

Summary

• Symbol: Klra1^em1Wyok
• Name: killer cell lectin-like receptor, subfamily A, member 1; endonuclease-mediated mutation 1, Wayne Yokoyama
• MGI ID: MGI:6460358
• Synonyms: Ly49A^-
• Gene: Klra1 Location: Chr6:130340881-130363837 bp, - strand Genetic Position: Chr6, 63.44 cM
• Alliance: Klra1^em1Wyok page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was targeted using sgRNAs with CRISPR/Cas9 technology. Four different out-of-frame insertion/deletion-insertion allele mouse lines were created, named A15 (TTTAG deletion - AGCT insertion), A20 (AGTCTC deletion -T insertion), AG1 (A insertion), and AG7 (A insertion). (J:295190)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klra1 Mutation: 17 strains or lines available

References

• Original: J:295190 Parikh BA, et al., Control of Viral Infection by Natural Killer Cell Inhibitory Receptors. Cell Rep. 2020 Jul 28;32(4):107969
• All: 1 reference(s)