Rasgrf1^tm1aNarl
Targeted Allele Detail

Summary

• Symbol: Rasgrf1^tm1aNarl
• Name: RAS protein-specific guanine nucleotide-releasing factor 1; targeted mutation 1a, National Laboratory Animal Center
• MGI ID: MGI:6460115
• Gene: Rasgrf1 Location: Chr9:89791961-89909030 bp, + strand Genetic Position: Chr9, 47.31 cM
• Alliance: Rasgrf1^tm1aNarl page

Mutation origin

• Mutant Cell Line: WCW_1413_003
• Germline Transmission: Earliest citation of germline transmission: J:295249
• Parent Cell Line: WCW (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion Vector: L1L2_Pgk_P Vector Type: Not Applicable
• Mutation details: The targeting construct inserted upstream of exon 2 an FRT site, En2 splice acceptor, IRES sequence, lacZ reporter gene, SV40 polyadenylation sequence, loxP site, neomycin resistance cassette, and loxP site. An additional loxP site was isnerted downstream of exon 2. (J:295249)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Rasgrf1 Mutation: 65 strains or lines available

References

• Original: J:295249 Tsai TH, et al., Deletion of RasGRF1 Attenuated Interstitial Fibrosis in Streptozotocin-Induced Diabetic Cardiomyopathy in Mice through Affecting Inflammation and Oxidative Stress. Int J Mol Sci. 2018 Oct 10;19(10):3094
• All: 2 reference(s)