Fmnl1^tm1Joja
Targeted Allele Detail

Summary

• Symbol: Fmnl1^tm1Joja
• Name: formin-like 1; targeted mutation 1, Jordan Jacobelli
• MGI ID: MGI:6458952
• Gene: Fmnl1 Location: Chr11:103061933-103089727 bp, + strand Genetic Position: Chr11, 66.71 cM, cytoband D
• Alliance: Fmnl1^tm1Joja page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294865
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: This allele was created using the EUCOMM project knockout-first targeting construct that places an FRT site, a strong splice acceptor site, a lacZ gene, a loxP site, a neomycin resistance gene cassette, a second FRT site and a second loxP site into intron 3 and a second loxP site into intron 6. Western blots confirmed the absence of protein expression from this allele. (J:294865)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fmnl1 Mutation: 48 strains or lines available

References

• Original: J:294865 Thompson SB, et al., Formin-like 1 mediates effector T cell trafficking to inflammatory sites to enable T cell-mediated autoimmunity. Elife. 2020 Jun 8;9:e58046
• All: 2 reference(s)