Tgfbr1^em1Mllo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tgfbr1^em1Mllo
• Name: transforming growth factor, beta receptor I; endonuclease-mediated mutation 1, Moises Mallo
• MGI ID: MGI:6458943
• Synonyms: Tgfbr1^-
• Gene: Tgfbr1 Location: Chr4:47353258-47414926 bp, + strand Genetic Position: Chr4, 26.02 cM
• Alliance: Tgfbr1^em1Mllo page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: The TGATGATAGGATCC sequence, containing three stop codons in frame with the open reading frame and a BamHI restriction site, was inserted into exon 2 using an sgRNA and an ssDNA template with CRISPR/Cas9. (J:294824)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr1 Mutation: 32 strains or lines available

References

• Original: J:294824 Dias A, et al., A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation. Elife. 2020 Jun 29;9:e56615
• All: 2 reference(s)