Il21^tm1(CD2)Kubo
Targeted Allele Detail

Summary

• Symbol: Il21^tm1(CD2)Kubo
• Name: interleukin 21; targeted mutation 1, Masato Kubo
• MGI ID: MGI:6457571
• Synonyms: IL-21 huCD2
• Gene: Il21 Location: Chr3:37276908-37286785 bp, - strand Genetic Position: Chr3, 18.36 cM, cytoband B
• Alliance: Il21^tm1(CD2)Kubo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181626
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Using a BAC containing the mouse Il21 gene, IRES sequence, the cDNA for human CD2 and poly(A) signal sequence was inserted in the 3' UTR of the endogenous locus. (J:181626)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il21 Mutation: 43 strains or lines available

References

• Original: J:181626 Harada Y, et al., The 3' Enhancer CNS2 Is a Critical Regulator of Interleukin-4-Mediated Humoral Immunity in Follicular Helper T Cells. Immunity. 2012 Feb 24;36(2):188-200
• All: 1 reference(s)