Tg(Cd4-CD2)aDarl
Transgene Detail

Summary

• Symbol: Tg(Cd4-CD2)aDarl
• Name: transgene insertion a, Dan R Littman
• MGI ID: MGI:6456182
• Transgene: Tg(Cd4-CD2)aDarl Location: unknown
• Alliance: Tg(Cd4-CD2)aDarl page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cd4-CD2)aDarl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD2 (914)

  Cd2	(MGI:88320)

  mouse promoter, human cDNA

• Tg(Cd4-CD2)aDarl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cd4 (MGI:88335)

• Mutation details: A mouse Cd4 minigene consisting of the upstream promoter (0.5 kb), 5' UTR-containing exon 1, intron 1 (8.6 kb) and the 5' UTR part of the start codon-containing exon 2, was linked to the human CD2 cDNA sequence, followed by SV40 poly(A) signal sequence. (J:18902)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:18902 Sawada S, et al., A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development. Cell. 1994 Jun 17;77(6):917-29
• All: 1 reference(s)