Irf4^tm1.1Axk
Targeted Allele Detail

Summary

• Symbol: Irf4^tm1.1Axk
• Name: interferon regulatory factor 4; targeted mutation 1.1, Axel Kallies
• MGI ID: MGI:6456139
• Synonyms: Irf4^GFP
• Gene: Irf4 Location: Chr13:30933209-30950959 bp, + strand Genetic Position: Chr13, 13.28 cM, cytoband A3.3
• Alliance: Irf4^tm1.1Axk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259282
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An IRES, followed by the EGFP reporter gene was inserted into the 3' UTR of exon 8. The neomycin resistance gene cassette that was also inserted was subsequently removed. (J:259282)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf4 Mutation: 35 strains or lines available

References

• Original: J:259282 Man K, et al., Transcription Factor IRF4 Promotes CD8(+) T Cell Exhaustion and Limits the Development of Memory-like T Cells during Chronic Infection. Immunity. 2017 Dec 19;47(6):1129-1141.e5
• All: 1 reference(s)