Il22^tm1Sckd
Targeted Allele Detail

Summary

• Symbol: Il22^tm1Sckd
• Name: interleukin 22; targeted mutation 1, Scott K Durum
• MGI ID: MGI:6455744
• Synonyms: IL22promTdtomato
• Gene: Il22 Location: Chr10:118040847-118045952 bp, + strand Genetic Position: Chr10, 66.67 cM
• Alliance: Il22^tm1Sckd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294335
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: Using recombineering with BAC RP23-401E11, the tdTomato red fluorescent gene (including SV40 poly(A) signal sequences) was inserted into exon 1, interrupting the endogenous signal peptide sequence. This creates a reporter knockout allele with the reporter gene driven by the endogenous promoter. (J:294335)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il22 Mutation: 27 strains or lines available

References

• Original: J:294335 Shen W, et al., IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice. Front Immunol. 2015;6:662
• All: 4 reference(s)