Polr3gl^tm1.2Rgr
Targeted Allele Detail

Summary

• Symbol: Polr3gl^tm1.2Rgr
• Name: polymerase (RNA) III (DNA directed) polypeptide G like; targeted mutation 1.2, Robert G Roeder
• MGI ID: MGI:6455431
• Synonyms: Polr3gl^delta
• Gene: Polr3gl Location: Chr3:96485188-96501497 bp, - strand Genetic Position: Chr3, 41.93 cM
• Alliance: Polr3gl^tm1.2Rgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291033
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette and Cre-mediated recombination removed exons 2 and 3. (J:291033)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Polr3gl Mutation: 21 strains or lines available

References

• Original: J:291033 Wang X, et al., Functions of paralogous RNA polymerase III subunits POLR3G and POLR3GL in mouse development. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15702-15711
• All: 1 reference(s)