Polr3g^tm1.1Rgr
Targeted Allele Detail

Summary

• Symbol: Polr3g^tm1.1Rgr
• Name: polymerase (RNA) III (DNA directed) polypeptide G; targeted mutation 1.1, Robert G Roeder
• MGI ID: MGI:6455428
• Synonyms: Polr3g^fl
• Gene: Polr3g Location: Chr13:81821962-81859132 bp, - strand Genetic Position: Chr13, 43.68 cM
• Alliance: Polr3g^tm1.1Rgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291033
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The HTGR04004_Z_1_E09 targeting vector inserted an FRT site, lacZ reporter gene, loxP sit, neomycin resistance cassette, FRT site, and loxP site upstream of exon 3. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the reporter and selection cassette, leaving exon 3 floxed. (J:291033)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Polr3g Mutation: 40 strains or lines available

References

• Original: J:291033 Wang X, et al., Functions of paralogous RNA polymerase III subunits POLR3G and POLR3GL in mouse development. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15702-15711
• All: 1 reference(s)