Adprs^tm1.2Jlms
Targeted Allele Detail

Summary

• Symbol: Adprs^tm1.2Jlms
• Name: ADP-ribosylserine hydrolase; targeted mutation 1.2, Joel Moss
• MGI ID: MGI:6455175
• Synonyms: ARH3^D
• Gene: Adprs Location: Chr4:126210144-126215496 bp, - strand Genetic Position: Chr4, 60.36 cM
• Alliance: Adprs^tm1.2Jlms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:291285
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette was inserted upstream of a floxed exon 3. Flp-mediated recombination removed the selection cassette and cre-mediated recombination removed exon 3. (J:291285)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adprs Mutation: 18 strains or lines available

References

• Original: J:291285 Mashimo M, et al., PARP1 inhibition alleviates injury in ARH3-deficient mice and human cells. JCI Insight. 2019 Feb 21;4(4)
• All: 1 reference(s)