St8sia6^em1Viss
Endonuclease-mediated Allele Detail

Summary

• Symbol: St8sia6^em1Viss
• Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6; endonuclease-mediated mutation 1, Virginia Smith Shapiro
• MGI ID: MGI:6453873
• Synonyms: ST8Sia6 KO
• Gene: St8sia6 Location: Chr2:13659745-13798659 bp, - strand Genetic Position: Chr2, 10.09 cM
• Alliance: St8sia6^em1Viss page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• A 10 bp deletion was created in exon 4 using TALENS. (J:293488)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any St8sia6 Mutation: 18 strains or lines available

References

• Original: J:293488 Belmonte PJ, et al., Cutting Edge: ST8Sia6-Generated alpha-2,8-Disialic Acids Mitigate Hyperglycemia in Multiple Low-Dose Streptozotocin-Induced Diabetes. J Immunol. 2020 Jun 15;204(12):3071-3076
• All: 2 reference(s)