Six6^tm1.1Plm
Targeted Allele Detail

Summary

• Symbol: Six6^tm1.1Plm
• Name: sine oculis-related homeobox 6; targeted mutation 1.1, Pamela L Mellon
• MGI ID: MGI:6452924
• Synonyms: Six6^flox
• Gene: Six6 Location: Chr12:72986666-72991673 bp, + strand Genetic Position: Chr12, 30.31 cM
• Alliance: Six6^tm1.1Plm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279114
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The EUCOMM vector ETPG00270_Y_5_D06 was used to create a conditional allele with an loxP, FRT, lacZ reporter gene, loxP, neomycin resistance cassette, and FRT site were inserted into exon 1 and an additional loxP site upstream of exon 2. Flp-mediated recombination removed the reporter gene and selection cassette and left most of exon 1 floxed. (J:279114)

Expression

In Mice Carrying this Mutation:

12 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Six6 Mutation: 16 strains or lines available

References

• Original: J:279114 Pandolfi EC, et al., Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility. Endocrinology. 2019 Sep 1;160(9):2151-2164
• All: 3 reference(s)