Six6tm1.1Plm
Targeted Allele Detail
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Symbol: |
Six6tm1.1Plm |
Name: |
sine oculis-related homeobox 6; targeted mutation 1.1, Pamela L Mellon |
MGI ID: |
MGI:6452924 |
Synonyms: |
Six6flox |
Gene: |
Six6 Location: Chr12:72986666-72991673 bp, + strand Genetic Position: Chr12, 30.31 cM
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Alliance: |
Six6tm1.1Plm page
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Germline Transmission: |
Earliest citation of germline transmission:
J:279114
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6J
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: The EUCOMM vector ETPG00270_Y_5_D06 was used to create a conditional allele with an loxP, FRT, lacZ reporter gene, loxP, neomycin resistance cassette, and FRT site were inserted into exon 1 and an additional loxP site upstream of exon 2. Flp-mediated recombination removed the reporter gene and selection cassette and left most of exon 1 floxed.
(J:279114)
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Original: |
J:279114 Pandolfi EC, et al., Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility. Endocrinology. 2019 Sep 1;160(9):2151-2164 |
All: |
3 reference(s) |
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