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Six6tm1.1Plm
Targeted Allele Detail
Nomenclature
Symbol: Six6tm1.1Plm
Name: sine oculis-related homeobox 6; targeted mutation 1.1, Pamela L Mellon
MGI ID: MGI:6452924
Synonyms: Six6flox
Gene: Six6  Location: Chr12:72986666-72991673 bp, + strand  Genetic Position: Chr12, 30.31 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:279114
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe EUCOMM vector ETPG00270_Y_5_D06 was used to create a conditional allele with an loxP, FRT, lacZ reporter gene, loxP, neomycin resistance cassette, and FRT site were inserted into exon 1 and an additional loxP site upstream of exon 2. Flp-mediated recombination removed the reporter gene and selection cassette and left most of exon 1 floxed. (J:279114)
Expression
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Six6 Mutation:  9 strains or lines available
References
Original:  J:279114 Pandolfi EC, et al., Deletion of the Homeodomain Protein Six6 From GnRH Neurons Decreases GnRH Gene Expression, Resulting in Infertility. Endocrinology. 2019 Sep 1;160(9):2151-2164
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory