Ctsd^tm1.1Yuch
Targeted Allele Detail

Summary

• Symbol: Ctsd^tm1.1Yuch
• Name: cathepsin D; targeted mutation 1.1, Yasuo Uchiyama
• MGI ID: MGI:6452457
• Synonyms: CD^flox, CTSD^Flox
• Gene: Ctsd Location: Chr7:141929647-141941564 bp, - strand Genetic Position: Chr7, 87.93 cM
• Alliance: Ctsd^tm1.1Yuch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243582
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Using BAC RP23-145I16, a loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 2. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 2 floxed. (J:243582)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctsd Mutation: 21 strains or lines available

References

• Original: J:243582 Koike M, et al., Purkinje Cells Are More Vulnerable to the Specific Depletion of Cathepsin D Than to That of Atg7. Am J Pathol. 2017 Jul;187(7):1586-1600
• All: 3 reference(s)