Cfh^tm1.1Mcp
Targeted Allele Detail

Summary

• Symbol: Cfh^tm1.1Mcp
• Name: complement component factor h; targeted mutation 1.1, Matthew Pickering
• MGI ID: MGI:6452242
• Synonyms: Cfh^loxP
• Gene: Cfh Location: Chr1:140013593-140111149 bp, - strand Genetic Position: Chr1, 61.62 cM, cytoband F
• Alliance: Cfh^tm1.1Mcp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293180
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Using recombineering techniques, a loxP site was inserted into intron 1 and an FRT site flanked neomycin resisistance gene cassette and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 2 and 3 floxed. (J:293180)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfh Mutation: 98 strains or lines available

References

• Original: J:293180 Vernon KA, et al., Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy. J Am Soc Nephrol. 2016 May;27(5):1334-42
• All: 3 reference(s)