Tg(Rn1-rtTA2S*M2)#Cpmh
Transgene Detail

Summary

• Symbol: Tg(Rn1-rtTA2S*M2)#Cpmh
• Name: transgene insertion, Christian P M Hugo
• MGI ID: MGI:6452225
• Synonyms: mRen-rtTA2
• Transgene: Tg(Rn1-rtTA2S*M2)#Cpmh Location: unknown
• Alliance: Tg(Rn1-rtTA2S*M2)#Cpmh page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The entire gene sequence (exons and introns) in BAC RP23-240p23 was replaced with a modified rtTA2 sequence (lower bakground activity, higher doxycycline sensitivity and changes to adapt it to eukaryotic cells). This brings the expression of the tetracycline reverse trans-activator under the control of the mouse renin promoter. (J:263308)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:263308 Starke C, et al., Renin lineage cells repopulate the glomerular mesangium after injury. J Am Soc Nephrol. 2015 Jan;26(1):48-54
• All: 2 reference(s)