Kat5^tm2.1Jwl
Targeted Allele Detail

Summary

• Symbol: Kat5^tm2.1Jwl
• Name: K(lysine) acetyltransferase 5; targeted mutation 2.1, John W Lough
• MGI ID: MGI:6452179
• Synonyms: Kat5^loxP, Tip60^fl
• Gene: Kat5 Location: Chr19:5653042-5660265 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Kat5^tm2.1Jwl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251791
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into introns 2 and 11 of the gene.A neomycin phosphotransferase (neo) cassette in intron 2 was subsequently removed by mating with a mouse expressing a Flp recombinase transgene. (J:251791)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat5 Mutation: 28 strains or lines available

References

• Original: J:251791 Fisher JB, et al., Depletion of Tip60 from In Vivo Cardiomyocytes Increases Myocyte Density, Followed by Cardiac Dysfunction, Myocyte Fallout and Lethality. PLoS One. 2016;11(10):e0164855
• All: 11 reference(s)