Ssrp1^tm1.1Guk
Targeted Allele Detail

Summary

• Symbol: Ssrp1^tm1.1Guk
• Name: structure specific recognition protein 1; targeted mutation 1.1, Katerina Gurova
• MGI ID: MGI:6452085
• Synonyms: Ssrp1^fl
• Gene: Ssrp1 Location: Chr2:84867578-84877453 bp, + strand Genetic Position: Chr2, 49.45 cM
• Alliance: Ssrp1^tm1.1Guk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263623
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The EUCOMM targeting vector PG00202_Z_1_D01 inserted into intron 3 an FRT site, lacZ reporter gene, loxP site, neomycin resistance cassette, FRT site and loxP site. A third loxP site was inserted into intron 9. Flp-mediated recombination removed the reporter/selection cassette and left exons 4 through 9 floxed. (J:263623)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ssrp1 Mutation: 58 strains or lines available

References

• Original: J:263623 Sandlesh P, et al., Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene. PLoS One. 2018;13(6):e0199785
• All: 3 reference(s)