Nup85^tm1.2Yter
Targeted Allele Detail

Summary

• Symbol: Nup85^tm1.2Yter
• Name: nucleoporin 85; targeted mutation 1.2, Yuya Terashima
• MGI ID: MGI:6451083
• Synonyms: Frount-null
• Gene: Nup85 Location: Chr11:115455264-115474750 bp, + strand Genetic Position: Chr11, 80.87 cM
• Alliance: Nup85^tm1.2Yter page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292726
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted into intron 14 and a second loxP site downstream of exon 19. The neo cassette was removed through subsequent flp-mediated recombination and exons 15-19 were deleted through cre-mediated recombination. (J:292726)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nup85 Mutation: 50 strains or lines available

References

• Original: J:292726 Terashima Y, et al., Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties. Nat Commun. 2020 Jan 30;11(1):609
• All: 1 reference(s)